AZD9056 hydrochloride

SKU: orb1308606

Description

AZD9056 hydrochloride is a selective P2X7 receptor antagonist. It is utilized in research to investigate the role of P2X7 in inflammatory and neuropathic pain pathways, with applications in both in vitro binding assays and in vivo disease models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 345303-91-5
• MW: 455.46
• Purity: 99.68% (May vary between batches)
• Formula: C₂₄H₃₆Cl₂N₂O₂
• SMILES: Cl.OCCCNCCCc1ccc(Cl)c(c1)C(=O)NCC12CC3CC(CC(C3)C1)C2
• Target: P2X Receptor
• Solubility: DMSO:48 mg/mL (105.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM)

Bioactivity

• Target IC50:
  P2X7:11.2 nM
• In Vivo:
  Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues.
• In Vitro:
  The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in the HEK-hP2X7 cell line, indicating high selectivity for the receptor. Additionally, AZD9056 exhibits a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, AZD 9056 Hydrochloride, AZD 9056, AZD9056 hydrochloride, AZD9056 Hydrochloride, AZD-9056 Hydrochloride, AZD-9056 hydrochloride, AZD9056, AZD-9056, P2XRs, P2XReceptor, P2X7, P2X Receptor

Compound Identifiers

PubChem CID

10161380