AZD-9574

SKU: orb1297894

Description

AZD-9574

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 2756333-39-6
• MW: 428.44
• Purity: 98.46%
• Formula: C₂₁H₂₂F₂N₆O₂
• SMILES: CNC(=O)c1ccc(N2CCN(Cc3ccc4nc(C)c(=O)[nH]c4c3F)CC2)c(F)n1
• Target: PPAR,PARP
• Solubility: DMSO:3.84 mg/mL (8.96 mM)

Bioactivity

• In Vivo:
  In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice.
• In Vitro:
  AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PPAR, Peroxisome proliferator-activated receptors, Inhibitor, homologous recombination repair, HRR-deficient cells, HRR, HRD+, PARP1, inhibit, AZD 9574, AZD9574, AZD-9574, Advanced Solid Malignancy, aberrant DNA repair, breast cancer

Compound Identifiers

PubChem CID

162524593