AZD-26

SKU: orb1222735

Description

AZD-26 is an inhibitor of AKT.

Key Properties

• CAS Number: 1357158-81-6
• MW: 343.42
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁N₃O
• SMILES: NC1(CCC1)c2ccc(cc2)c3ncc(cc3c4ccccc4)C(N)=O
• Target: allosteric Akt
• Solubility: DMSO : 25 mg/mL 72.80 mM

Bioactivity

• In Vivo:
  The effects of AKT-IN-1 (Compound 26) In vivo are characterized by measuring the pharmacodynamic activity of AKT-IN-1 in a BT474c breast adenocarcinoma xenograft model. Following acute doses of 100 and 200 mg/kg, AKT-IN-1 potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473), with a potency consistent with its pharmacokinetic profile. In vivo activity of AKT-IN-1 is further characterized by measuring the effects on the growth of tumor cell xenografts. Continuous (daily) oral dosing of AKT-IN-1 (100 and 200 mg/kg) to nude mice bearing BT474c breast adenocarcinoma xenografts results in inhibition of tumor growth in a dose-dependent manner. When dosed at 200 mg/kg daily, AKT-IN-1 causes significant tumor growth inhibition.
• In Vitro:
  AKT-IN-1 is able to potently inhibit phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM, respectively. AKT-IN-1 inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway. AKT-IN-1 potently inhibits the phosphorylation of PRAS40.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD-26 | AZD 26 | AZD26

Quick Database Links

Gene Symbol

allosteric Akt