AZ3976

SKU: orb1703709

Description

AZ3976 is a small molecule PAI-1 inhibitor with an IC50 of 16 μM in a plasma clot lysis assay, demonstrating profibrinolytic activity. It is a research tool for studying fibrinolysis in thrombosis and cardiovascular disease models, applicable in both in vitro and in vivo experimental settings.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1418747-15-5
• MW: 317.34
• Purity: 98.01% (May vary between batches)
• Formula: C₁₅H₁₉N₅O₃
• SMILES: O=C1C=2C(NC(NC3CN(C(OC(C)(C)C)=O)C3)=N1)=NC=CC2
• Target: PAI-1
• Solubility: DMSO:45 mg/mL (141.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.3 mM)

Bioactivity

• In Vitro:
  AZ3976 is active with an IC50 value of 26 μM in an enzymatic chromogenic assay. AZ3976 enhances the latency transition of active PAI-1 and inhibits PAI-1.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZ3976, AZ-3976, AZ 3976, PAI1, PAI-1

Compound Identifiers

PubChem CID

135566649