AZ084

SKU: orb1309959

Description

AZ084 is a potent and selective allosteric CCR8 antagonist with oral bioavailability, exhibiting a Ki of 0.9 nM. It is a valuable research tool for investigating CCR8 biology in asthma and other inflammatory diseases, with applications in both in vitro binding assays and in vivo preclinical models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 929300-19-6
• MW: 434.57
• Purity: 98.34% (May vary between batches)
• Formula: C₂₆H₃₄N₄O₂
• SMILES: CC1(C)Cc2c(O1)cccc2CN1CCC2(CC1)CCN(CC2)C(=O)c1ccc(N)cn1
• Target: CCR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.51 mM);DMSO:240 mg/mL (552.27 mM)

Bioactivity

• Target IC50:
  CCR8:0.9 nM (ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PMN, asthma, AZ084, AZ-084, AZ 084, CCR, CC chemokine receptor, CCR8, tumor metastasis, Tregs differentiation, T cells

Compound Identifiers

PubChem CID

16065569