AZ 5704

SKU: orb1694177

Description

This orally bioavailable, highly potent and selective ATM kinase inhibitor (enzyme IC50 = 0.6 nM) demonstrates >600-fold selectivity and cellular activity (IC50 = 0.33 µM). It is a valuable research tool for studying DNA damage response and has been shown to potentiate irinotecan's antitumor effects in vivo.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 1941214-06-7
• MW: 434.47
• Purity: 99.69%
• Formula: C₂₃H₂₃FN₆O₂
• SMILES: N([C@@H](C)C1=NN(C)C=C1)C=2C3=C(C=C(F)C(=C3)C=4C=CC(COC)=NC4)N=CC2C(N)=O
• Target: ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

130470684