Axitinib-13C-d3

SKU: orb3054063

Description

Axitinib-13C,d3 is a 13C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 andPDGFRβ, respectively.

Key Properties

• CAS Number: 1261432-00-1
• MW: 390.48
• Purity: >98% (HPLC)
• Formula: C₂₁₁₃CH₁₅D₃N₄OS
• Solubility: DMSO : ≥ 2.5 mg/mL (6.40 mM ) DMF : ≥ 0.25 mg/mL (0.64 mM)

Bioactivity

• In Vitro:
  Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only