Atherosperminine

SKU: orb1297122

Description

Atherosperminine is a dual cholinesterase inhibitor, active against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Its tracheal smooth muscle relaxant effect is primarily attributed to cAMP phosphodiesterase inhibition, making it a research tool for studying respiratory and neurological mechanisms in vitro.

Research Area

Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5531-98-6
• MW: 309.4
• Purity: 99.92% (May vary between batches)
• Formula: C₂₀H₂₃NO₂
• SMILES: O(C)C=1C=2C(C(CCN(C)C)=CC1OC)=CC=C3C2C=CC=C3
• Target: cAMP,Calcium Channel,Parasite,AChR
• Solubility: DMSO:50 mg/mL (161.6 mM)

Bioactivity

• Target IC50:
  Antiplasmodial:5.80 μM|DPPH:54.53 ug/mL
• In Vitro:
  Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with the IC50 value of 5.80 μM. Atherosperminine also shows antioxidant activity in a DPPH assay with the IC50 value of 54.53 ug/mL.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChR, Atherospermine, Atherosperminine, antiplasmodial, Calcium Channel, cAMP, BChE, DPPH, CalciumChannel, Parasite, inhibit, Inhibitor, reductants, trachealis, pro-oxidant

Compound Identifiers

PubChem CID

96918