ATB107 hydrochloride

SKU: orb1819298

Description

ATB107 hydrochloride is a potent small molecule inhibitor targeting indole-3-glycerol phosphate synthase (IGPS), exhibiting a binding affinity (K_D) of 3 µM. This compound is a valuable research tool for studying tryptophan biosynthesis in microbial systems, applicable in both biochemical and cellular assays.

Key Properties

• MW: 428.96
• Purity: 99.06% (May vary between batches)
• Formula: C₂₁H₂₉ClN₈
• SMILES: N1(C2=NC(NC3=CC=CC=C3)=NC(N/N=C4CN5CCC\4CC5)=N2)CCCCC1.Cl
• Target: Others
• Solubility: DMSO:4.29 mg/mL (10 mM)

Bioactivity

• In Vitro:
  The minimum inhibitory concentration (MIC) of ATB107 hydrochloride is 0.1 μg/mL for M. tuberculosis H37Ra. ATB107 hydrochloride also has high activity against M. tuberculosis H37Rv, with an MIC of 0.1 μg/mL. All 50 fully susceptible clinical isolates tested are susceptible to ATB107 at 1 μg/mL; of these, 41 (82%) are susceptible to ATB107 at 0.1 μg/mL. The results also show that 67 (83.8%) multidrug-resistant TB (MDR-TB) isolates are susceptible to ATB107 hydrochloride at 1 μg/mL, and 25 (31.3%) isolates are susceptible to ATB107 hydrochloride at 0.1 μg/mL. Results show that the binding ability of ATB107 hydrochloride is well correlated with its concentrations. At the highest concentration of 200 μg/mL, ATB107 hydrochloride can inhibit cell proliferation, with cell survival of about 60%. With the lower concentration of 50 μg/mL, cell survival is more than 80% for ATB107 hydrochloride.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

indole-3-glycerol phosphate synthase, ATB 107 Hydrochloride, ATB107 Hydrochloride, ATB-107 Hydrochloride, ATB107 hydrochloride(455325-51-6 Free base)

Compound Identifiers

PubChem CID

171340643