Atazanavir

SKU: orb1310936

Description

Atazanavir

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 198904-31-3
• MW: 704.9
• Purity: >98%
• Formula: C₃₈H₅₂N₆O₇
• SMILES: N(CC1=CC=C(C=C1)C2=CC=CC=N2)(C[C@@H]([C@H](CC3=CC=CC=C3)NC([C@@H](NC(OC)=O)[C@@](C)(C)C)=O)O)NC([C@@H](NC(OC)=O)[C@](C)(C)C)=O
• Target: P-gp,SARS-CoV,HIV Protease,Endogenous Metabolite,Cytochromes P450,TLR
• Solubility: Soluble in DMSO (45 mg/ml)

Bioactivity

• In Vivo:
  Atazanavir has excellent oral bioavailability in the range of 60-70%.
• In Vitro:
  Atazanavir has potent in vitro activity with 50 and 90% effective concentrations(EC50) of 2-5 nM and 9-15 nM respectively against wild type virus. Atazanavir is able to potently induce endoplasmic reticulum (ER) stress response in malignant glioma cells, as indicated by elevated levels of GRP78 and CHOP, and activation of caspase-4, which leads to cell death.
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• Cell Research:
  U251, T98 g, and LN229 glioblastoma cell lines are exposed to increasing concentrations of nelfinavir and atazanavir. Cells cultured in 96-well plates are treated with drugs for 48 h, and cell growth and survival are determined by conventional MTT assay.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS 232632; CGP 73547; Latazanavir

Compound Identifiers

PubChem CID

148192