ASIC1a antagonist-1

SKU: orb3136052

Description

ASIC1a antagonist-1 (Compound 5b) is an orthosteric non-competitive antagonist of the acid-sensing ion channel 1a (ASIC1a) with an IC50 of 27 nM at pH 6.7. It alters the pH dependency of ASIC1a activation and suppresses its maximum response. Additionally, ASIC1a antagonist-1 completely inhibits the induction of long-term potentiation (LTP) in the CA3-CA1 pathway. This compound is useful for research into brain diseases and pathologies.

Research Area

Neuroscience; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1787243-08-6
• MW: 499.86
• Formula: C₂₃H₂₉Cl₃N₄O₂
• SMILES: O=C1OC2=C(C=C1C(N)=N)C=CC(N(CCN(CC)CC)CC3=CC=C(C=C3)Cl)=C2.Cl.Cl
• Target: Sodium Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Sodium Channel