Ascamycin

SKU: orb1707638

Description

Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic from Streptomyces spp., exhibiting potent and selective antibacterial activity against Xanthomonas species and phage. It serves as a valuable research tool for in vitro studies of bacterial plant pathogens like X. citri and X. oryzae.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 91432-48-3
• MW: 451.84
• Purity: 97.10% (May vary between batches)
• Formula: C₁₃H₁₈ClN₇O₇S
• SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](COS(NC([C@H](C)N)=O)(=O)=O)[C@@H](O)[C@H]3O)=NC(Cl)=N1
• Target: Nucleoside Antimetabolite/Analog,Antibiotic,Antibacterial
• Solubility: DMSO:10 mg/mL (22.13 mM)

Bioactivity

• Target IC50:
  Xanthomonas citri:（MIC）0.4 μg/ml|Xanthomonas citri:0.4 μg/ml(MIC)|Mycobacterium phlei:12.5 μg/ml|Mycobacterium phlei:12.5 μg/ml(MIC)|Xanthomonas oryzae:12.5 μg/ml|Xanthomonas oryzae:12.5 μg/ml(MIC)
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• In Vitro:
  Ascamycin has a selective antibacterial activity against Xanthomonas species and it has C2-chloroadenine as the base on C-1' which lacks the chlorine. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface, When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Mycobacterium phlei, Antibiotic, Analog, Ascamycin, Bacterial, Xanthomonas citri, Xanthomonas oryzae

Compound Identifiers

PubChem CID

13994715