ARV-393 HCl

SKU: orb2308719

Description

ARV-393 HCl is a potent, orally bioavailable PROTAC degrader targeting the BCL6 oncoprotein. It demonstrates robust antitumor activity in both in vitro and in vivo models, making it a valuable chemical probe for researching B-cell non-Hodgkin's lymphomas.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• Target: Bcl-2 Family,Bcl-6,PROTACs
• Molecular Weight: 934.88
• Purity: 99.79%
• Formula: C₄₆H₅₄Cl₂FN₉O₇
• SMILES: Cl.CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)O[C@H]3C[C@@H](C3)N3CCC(CC3)c3ccc4C(=O)N(Cc4c3F)C3CCC(=O)NC3=O)ccc2n(C(C)C)c1=O

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARV-393 HCl(2851885-95-3 Free base), ARV393HCl(2851885953Freebase), BCL, PROTAC

Compound Identifiers

PubChem CID

172009643