ART899

• Catalog Number: orb2695186
• Category: Small Molecules
• Description: ART899, a derivative of ART558, is a potent and specific conformational inhibitor of DNA polymerase θ (Polθ). It specifically inhibits the MMEJ activity of Polθ with an IC50 of 180 nM. Additionally, ART899 selectively enhances the radiosensitivity of tumor cells and possesses a strong independent antitumor effect on cancer cells.
• MW: 464.81
• CAS Number: 2607139-85-3
• Formula: C₁₉H₁₆ClF₄N₃O₄
• SMILES: C(N(C([2H])([2H])[2H])C1=CC(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)[C@@H](O)[C@H]2O)C3=CC(C(F)(F)F)=CC(C)=N3
• Storage: -20°C
• Note: For research use only