ART899

SKU: orb2695186

Description

ART899 is a potent and specific conformational inhibitor of DNA polymerase θ (Polθ), derived from ART558, which suppresses microhomology-mediated end joining (MMEJ) with an IC50 of 180 nM. It demonstrates selective radiosensitization and independent antitumor activity in cancer cell studies, supporting research into DNA repair pathways and targeted cancer therapies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2607139-85-3
• MW: 464.81
• Formula: C₁₉H₁₆ClF₄N₃O₄
• SMILES: C(N(C([2H])([2H])[2H])C1=CC(Cl)=C(F)C=C1)(=O)[C@H]2N(C(=O)[C@@H](O)[C@H]2O)C3=CC(C(F)(F)F)=CC(C)=N3
• Target: DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156069563