Aristolochic acid B

SKU: orb1300129

Description

Aristolochic acid B

Research Area

Molecular Biology

Key Properties

• CAS Number: 475-80-9
• MW: 311.25
• Purity: 99.99% (May vary between batches)
• Formula: C₁₆H₉NO₆
• SMILES: OC(=O)c1cc2OCOc2c2c3ccccc3cc([N+]([O-])=O)c12
• Target: DNA
• Solubility: DMSO:10 mg/mL (32.13 mM);Chloroform:Soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.21 mM)

Bioactivity

• In Vivo:
  METHODS: Aristolochic acid B (Aristolochic Acid II) (5 mg/kg, intragastrically, 5 times a week for 6 weeks) was compared for DNA adduct formation and mutagenicity in the kidneys of gptδ transgenic mice. RESULTS Aristolochic acid B (Aristolochic Acid II) induced mutations at a frequency nearly two-fold higher than that induced by aristolochic acid I, showing a higher carcinogenic risk in vivo than aristolochic acid I, which may be at least partly the result of its elevated levels in the kidneys and plasma.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aristolochic acid B, Aristolochic Acid II, DNA mutation, inhibit, Inhibitor

Compound Identifiers

PubChem CID

108168