Arginine-glycine-aspartic acid

SKU: orb1300305

Description

The RGD peptide motif is a synthetic sequence that mimics natural cell adhesion proteins by binding to integrin receptors. It is widely used in vitro to study cell attachment, migration, and signaling, and in vivo for applications in biomaterial coating and targeted drug delivery research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 99896-85-2
• MW: 346.34
• Purity: 99.11% (May vary between batches)
• Formula: C₁₂H₂₂N₆O₆
• SMILES: N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O
• Target: Integrin
• Solubility: H2O:34.6 mM

Bioactivity

• In Vitro:
  The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Arg-Gly-Asp, inhibit, Inhibitor, Integrin, RGD, RGD (Arg-Gly-Asp) Peptides, RGD Peptides

Compound Identifiers

PubChem CID

104802