Argatroban

SKU: orb1710747

Description

Argatroban

Research Area

Neuroscience

Key Properties

• CAS Number: 74863-84-6
• MW: 508.63
• Purity: >98%
• Formula: C₂₃H₃₆N₆O₅S
• SMILES: S(N[C@H](C(=O)N1[C@@H](C(O)=O)C[C@H](C)CC1)CCCNC(=N)N)(=O)(=O)C2=C3C(=CC=C2)CC(C)CN3
• Target: Protease
• Solubility: Soluble in DMSO (up to 50 mg/ml).

Bioactivity

• Target IC50:
  Thrombin:5-39 nM(Ki)
• In Vivo:
  Argatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM).
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• In Vitro:
  In a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Argidipine; MQPA

Compound Identifiers

PubChem CID

92722