Arazine

SKU: orb1309984

Description

Arazine is a cell-permeable, N-acetyl-S-farnesyl-L-cysteine derivative that modulates G protein and GPCR signaling by acting as a competitive substrate for isoprenylcysteine methyltransferase. This activity makes it a valuable research tool for investigating prenylated protein function in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 135304-07-3
• MW: 367.55
• Purity: 90.00% (May vary between batches)
• Formula: C₂₀H₃₃NO₃S
• SMILES: CC(C)=CCC\C(C)=C\CC\C(C)=C\CSC[C@H](NC(C)=O)C(O)=O
• Target: DNA Methyltransferase,Others

Bioactivity

• In Vivo:
  Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl.
• In Vitro:
  Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell-permeable, Arazine, inhibit, modulator, N-Acetyl-S-farnesyl-L-cysteine, Inhibitor, substrate

Compound Identifiers

PubChem CID

6438381