AP39 Free base

SKU: orb1694255

Description

AP39 is a mitochondria-targeted hydrogen sulfide donor used in research. It enhances porcine islet survival in culture and ameliorates doxorubicin-induced cardiac fibrosis in models by modulating mitophagy via the AMPK-ULK1-FUNDC1 pathway and suppressing pyroptosis.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1429173-57-8
• MW: 641.87
• Purity: 97.61% (May vary between batches)
• Formula: C₃₇H₃₈O₂PS₃
• SMILES: O=C(OC=1C=CC(=CC1)C=2SSC(=S)C2)CCCCCCCCC[P+](C=3C=CC=CC3)(C=4C=CC=CC4)C=5C=CC=CC5
• Target: Others,ROS
• Solubility: DMF:5 mg/mL (7.79 mM);DMSO:20 mg/mL (31.16 mM);Ethanol:16 mg/mL (24.93 mM);PBS (pH 7.2):1 mg/mL (1.56 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (0.78 mM)

Bioactivity

• In Vivo:
  In the AP39 +ISO group, the deposition of collagen fibers mentioned above was reduced compared to the ISO group. In comparison to the AP39 +ISO group, the AP39 +ISO+PAG group showed a significant increase in collagen fiber deposition. There was no significant difference in myocardial collagen deposition between the AP39 +ISO+PAG group and the ISO group. Moreover, no significant difference in myocardial collagen fiber deposition was observed between the AP39 group and the Control group.
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• In Vitro:
  AP39 inhibits excessive mitochondrial autophagy through the PINK1/Parkin pathway in cardiomyocytes. The results showed that CSE protein expression levels were significantly decreased in the CoCl2 group, while the intervention with AP39 significantly upregulated CSE protein expression levels. This effect of AP39 was reversed by the endogenous H2S synthesis inhibitor PAG.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP39, AP-39, AP-39 Free base, AP 39, AP 39 Free base

Compound Identifiers

PubChem CID

71537389