AOH1996

SKU: orb1819088

Description

AOH1996 is an orally bioavailable PCNA-targeting ligand that disrupts transcription-replication conflicts. It stabilizes PCNA-RNA polymerase II interactions, inducing proteasomal degradation of RPB1, DNA damage, and apoptosis. This molecule shows synergistic activity with genotoxic agents in preclinical cancer models, providing a research tool for studying replication stress and combination therapies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2089314-64-5
• MW: 426.46
• Purity: 98.80% (May vary between batches)
• Formula: C₂₆H₂₂N₂O₄
• SMILES: C(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
• Target: Apoptosis|||DNA
• Solubility: DMSO:250 mg/mL (586.22 mM)

Bioactivity

• Target IC50:
  PDAC cells:0.72 μM|KRAS (G12D):0.93 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, AOH 1996, AOH1996, AOH-1996, apoptosis, PCNA

Compound Identifiers

PubChem CID

126718388