Antifreeze Polypeptide (AFP) (HPLC-6), Winter Flounder

SKU: orb3053919

Description

Antifreeze Polypeptide 6 (winter flounder) is the component 6 of the winter flounder's antifreeze polypeptides. Antifreeze Polypeptide 6 (winter flounder) lowers the plasma freezing point by arresting the growth of ice nuclei.

Research Area

Cancer Biology

Key Properties

• CAS Number: 122604-16-4
• MW: 3242.53
• Purity: >98% (HPLC)
• Formula: C₁₃₃H₂₂₅N₄₃O₅₁
• Solubility: H2O : 45.45 mg/mL (14.02 mM; adjust pH to 1 with 1 M HCL)

Bioactivity

• In Vitro:
  Antifreeze Polypeptide 6 (winter flounder) inhibits the growth of ice crystals by hydrogen bonding of Thr, Asn, and Asp side chains in a specific pattern to the hexagonal bipyramidal planes of ice. This mode of binding is unidirectional, maximizing opportunities for packing of AFPs on the ice surface, and that ice crystal growth inhibition occurs by a two-step mechanism involving hydrogen bonding and hydrophobic interpeptide interactions.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only