Antibacterial agent 284

SKU: orb3135049

Description

Antibacterialagent 284 (Compound 7) is an antibacterial agent with a zinc-binding structure, showing potent inhibitory activity against the Legionella pneumophila metalloprotease ProA, with an IC50 of 0.96 μM. It effectively inhibits the cleavage of type IV collagen and flagellin (ProA substrates), and reduces immune evasion within the TLR5-NF-κB pathway and neutrophil (PMN)-mediated inflammation in human lung tissue explants. Antibacterialagent 284 holds potential for Legionnaires' disease research.

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Key Properties

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Target	Antibacterial,TLR,Others

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Antibacterial,TLR,Others

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