Anserine

SKU: orb1306053

Description

Anserine (L-Anserine) is a β-alanine-histidine dipeptide found in vertebrate muscle and brain. It resists serum carnosinase and functions as a buffer, antioxidant, and anti-glycation agent. Research applications include studies on neuroprotection, with in vivo models demonstrating memory improvement in Alzheimer's disease mice.

Research Area

Metabolism Research

Key Properties

• CAS Number: 584-85-0
• MW: 240.26
• Purity: 99.91% (May vary between batches)
• Formula: C₁₀H₁₆N₄O₃
• SMILES: C([C@H](NC(CCN)=O)C(O)=O)C=1N(C)C=NC1
• Target: Endogenous Metabolite
• Solubility: H2O:250 mg/mL (1040.54 mM);DMSO:Insoluble

Bioactivity

• In Vivo:
  Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anserine, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, L-Anserine, inhibit

Compound Identifiers

PubChem CID

112072