Anisodamine B

SKU: orb2901499

Description

Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning.

Key Properties

• CAS Number: 55869-99-3
• MW: 305.37
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₃NO₄
• SMILES: CN1[C@@H]2C[C@H](O)[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c1ccccc1
• Target: AChR
• Solubility: In Vitro: DMSO : ≥ 100 mg/mL (327.47 mM; )H2O : 20 mg/mL (65.49 mM; Ultrasonic)

Bioactivity

• In Vivo:
  Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%. Animal model: LPS-Induced Shock Mice. Dosage: 50 mg/kg. Administration: i.p. Result: Markedly decreased the mortality to 20%.
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• In Vitro:
  Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone. Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR