Aniracetam

SKU: orb1224140

Description

Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.(In Vitro):Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells.Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.(In Vivo):Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats.Aniracetam (10-100 mg/kg; p.o.; single dosage) prevents the CO2-induced impairment of acquisition in rats.Aniracetam (30-300 mg/kg; p.o.; single dosage) increases the percentage of rats showing passive avoidance.

Key Properties

• CAS Number: 72432-10-1
• MW: 219.24
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₃NO₃
• SMILES: O=C1N(C(C2=CC=C(OC)C=C2)=O)CCC1
• Target: 5-HT Receptor
• Solubility: Ethanol: 18 mg/mL (82.1 mM); DMSO: 44 mg/mL (200.69 mM)

Bioactivity

• In Vivo:
  Aniracetam (1 mM; 30-75 min) potentiates the iQA receptors and produces remarkable facilitation of the native synaptic transmission in rats. Aniracetam (10-100 mg/kg; p.o. ; single dosage) prevents the CO2-induced impairment of acquisition in rats. Aniracetam (30-300 mg/kg; p.o. ; single dosage) increases the percentage of rats showing passive avoidance. Animal model: Pyramidal neurons from male Wistar rats. Dosage: 1 mM. Administration: 30-75 min. Result: Potentiated the iQA receptors existing in the brain and produced remarkable facilitation of the native synaptic transmission. Animal model: Male rats (100-120 g; hypercapnia induced by pure CO2). Dosage: 10, 30, 50 and 100 mg/kg. Administration: p.o. ; single dosage (60 min before hypercapnia). Result: Significantly prevented the CO2-induced impairment of acquisition at 30 and 50 mg/kg. Animal model: Male rats and male mice (100-120 g and 21-25 g; 0.5 mg/kg Scopolamine-induced transient disruption of the memory of a passive avoidance procedure). Dosage: 30, 50, 100 and 300 mg/kg,. Administration: p.o. ; single dosage. Result: Significantly increased the percentage of rats showing passive avoidance 2 h after Scopolamine (HY-N0296) at 50 and 100 mg/kg.
• In Vitro:
  Aniracetam concentration-dependently counteracts glutsmate-, kainate-, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death and greatly facilitated neuroprotective response achieved by different concentrations of both quisqualate and trans-1-aminocyclopentane-1, 3-dicarboxylate in primary cultures of cerebellar granule cells. Aniracetam potentiates the mGluR-coupled stimulation of phospholipase C in primary cultures of cerebellar granule cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Memodrin | Ro 13-5057 | Sarpul

Quick Database Links

Gene Symbol

5-HT Receptor