Anidulafungin

SKU: orb1301084

Description

Anidulafungin

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 166663-25-8
• MW: 1140.24
• Purity: 99.15%
• Formula: C₅₈H₇₃N₇O₁₇
• SMILES: [H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](O)NC(=O)[C@]1([H])[C@@H](O)[C@@H](C)CN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@@H](C)O)NC(=O)c1ccc(cc1)-c1ccc(cc1)-c1ccc(OCCCCC)cc1)[C@@H](C)O
• Target: Antifungal,Antibiotic
• Solubility: DMSO:93 mg/mL (81.56 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:3.3 mg/mL (2.89 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  Anidulafungin (LY-303366) demonstrates potent in vitro antifungal activity, with minimum inhibitory concentrations (MICs) of ≤0.32 μg/mL against all isolates of Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10). It exhibits significant efficacy against Aspergillus species with a minimum effective concentration (MEC) of 0.02 μg/mL for 90% inhibition (n=20). However, its activity is reduced against Candida parapsilosis (MIC90, 5.12 μg/mL) (n=10), and it is ineffective against C. neoformans (MIC90 >10.24 μg/mL) (n=15) and B. dermatitidis (MIC90, 16 μg/mL) (n=29). Compared to fluconazole, anidulafungin retains low MICs (0.08 to 1.28 μg/mL) against fluconazole-resistant Candida strains, demonstrating a broad range of action. Strains showing resistance to CD101 exhibit a corresponding increase in MIC for anidulafungin and/or caspofungin, highlighting cross-resistance. This strong antifungal activity, notably against Candida species and Aspergillus, contrasts with its limited effects against C. neoformans and B. dermatitidis, for which ketoconazole and amphotericin B show superior efficacy.
• Cell Research:
  Anidulafungin is dissolved in DMSO and stored, and then diluted. Stocks of CD101 (formerly SP 3025, biafungin, AF-025) are prepared fresh in 100% DMSO prior to use. The comparator antifungals Anidulafungin (ANF), Caspofungin (CSF), and Amphotericin B (AMB) are also prepared in 100% DMSO. MIC assays are performed via broth microdilution in accordance with CLSI guidelines, with the exception that test compounds are made up at a 50× final assay concentration and 100 μL assay mixture volumes are used (2 μL added to 98 μL of broth containing cells at 0.5×103 to 2.5×103 CFU/mL). All MIC assays are run at least three times, and a representative data set is shown. Quality control (QC) is assessed throughout the study via comparison of MIC values derived for WT C. krusei strain ATCC 6258 for AMB, CSF, and ANF with previously reported CLSI 24-h broth microdilution QC ranges.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anidulafungin, Antibiotic, Fungal, glucan synthase, Eraxis, Ecalta, Inhibitor, inhibit, LY 303366, LY303366, LY-303366

Compound Identifiers

PubChem CID

166548