Ampreloxetine hydrochloride

SKU: orb1745213

Description

Ampreloxetine hydrochloride (TD-9855 HCl) is a small molecule exhibiting anti-inflammatory properties, positioning it as a candidate for research into depression and Alzheimer's disease. Its mechanism, involving norepinephrine and serotonin transporter inhibition, has been investigated in preclinical in vitro and in vivo models for neuropsychiatric and neurodegenerative disorders.

Research Area

Neuroscience

Key Properties

• CAS Number: 1227056-87-2
• MW: 357.8
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₁₉ClF₃NO
• SMILES: Cl.FC=1C=C(F)C(OCC=2C=CC=CC2C3CCNCC3)=C(F)C1
• Target: Serotonin Transporter,Others
• Solubility: DMSO:50 mg/mL (139.74 mM)

Bioactivity

• Target IC50:
  rat Serotonin transporter:8.9 (pIC50)|Norepinephrine transporter (human):8.0 (pIC50)|Norepinephrine transporter (rat):7.9 (pIC50)|Serotonin transporter (human):8.6 (pIC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TD-9855 HCl, Ampreloxetine Hydrochloride

Compound Identifiers

PubChem CID

46189894