AMPK activator 4

SKU: orb1687802

Description

AMPK Activator 4 is a potent, muscle-selective AMPK activator that improves glucose tolerance and insulin sensitivity without inhibiting mitochondrial complex I. It demonstrates significant hypoglycemic effects in diabetic mouse models, making it a valuable research tool for studying metabolic diseases and AMPK signaling pathways in vivo and in vitro.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 2493239-46-4
• MW: 420.89
• Purity: 99.46% (May vary between batches)
• Formula: C₂₄H₂₁ClN₂O₃
• SMILES: CC(C)(Oc1ccc(Cl)cc1)C(=O)Nc1ccc(OCc2ccc(cc2)C#N)cc1
• Target: AMPK
• Solubility: DMSO:50 mg/mL (118.8 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.94 mM)

Bioactivity

• In Vivo:
  AMPK activator 4 (100 mg/kg; intragastrical administration; daily for 9 weeks; db/db mice) significantly lowered fasting blood glucose in db/db mice (2-6 weeks) and significantly improved insulin resistance (for 9 weeks), without significantly affecting body weight or serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), demonstrating an anti-hyperglycemic effect.
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• In Vitro:
  AMPK activator 4 (compound B10) (10-20 μM; 72 h) slightly decreases the viability of HepG2 cells. AMPK activator 4 (0-20 μM; 12-24 h) induces dose-dependent phosphorylation of ACC in C2C12 myotube cells, with this phosphorylation being consistent with AMPK phosphorylation. Additionally, it increases AMPK and ACC phosphorylation in HepG2 and HuH-7 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK

Compound Identifiers

PubChem CID

154573764