Ampalex

SKU: orb1226122

Description

Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).(In Vitro):.(In Vivo):The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s.c.).

Key Properties

• CAS Number: 154235-83-3
• MW: 241.29
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₅N₃O
• SMILES: O=C(N1CCCCC1)C2=CC=C3N=CC=NC3=C2
• Target: GluR
• Solubility: DMSO: 40 mg/mL

Bioactivity

• In Vivo:
  The specific extradimensional deficits produced by sub-chronic or early postnatal postnatal phencyclidine treatment were significantly attenuated by CX516 (10, and 20 mg/kg, s. c.). Animal model: Male Lister Hooded rats (56-63 postnatal day). Dosage: 5, 10, 20, and 40 mg/kg. Administration: Subcutaneously. Result: Two doses (10 and 20 mg/kg) were highly significant in improving the extradimensional shift deficit induced by either treatment regimes. Two doses (5 and 40 mg/kg) was ineffective at reversing the extradimensional impairment induced by the sub-chronic postnatal phencyclidine treatment regime.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ampalex | BDP-12 | Benzoyl-Piperidine-12

Quick Database Links

Gene Symbol

GluR