Amoxicillin trihydrate

SKU: orb1310071

Description

Amoxicillin trihydrate is a semisynthetic, broad-spectrum bactericidal antibiotic. It inactivates penicillin-binding proteins like PBP-1A, disrupting peptidoglycan cross-linking in the bacterial cell wall, leading to cell lysis. This compound is widely used in microbiological research for in vitro susceptibility testing and in vivo models of bacterial infection.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 61336-70-7
• MW: 419.45
• Purity: 98.90% (May vary between batches)
• Formula: C₁₆H₂₅N₃O₈S
• SMILES: O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(O)=O
• Target: Antibiotic,Antibacterial
• Solubility: DMSO:60 mg/mL (143.04 mM);H2O:1.25 mg/mL (2.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.38 mM)

Bioactivity

• In Vivo:
  A 25 microliter volume of a 1-% L-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduces blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes. Epinephrine is a direct-acting sympathomimetic α-adrenergic and β-adrenergic agonist with cyclic adenosine monophosphate-mediated, complex, bidirectional pharmacologic effects on many target organs. In young adult rats, endogenous release of epinephrine facilitates stable memory formation for temporally associated events. Epinephrine enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory. Epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest. Epinephrine increases arterial blood pressure and coronary perfusion during CPR via alpha-1-adrenoceptor agonist effects.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, PBPs, inhibit, Moxaline, Moxaline Trihydrate, Moxaline trihydrate, cell wall, Bacterial, Amoxicillin Trihydrate, Amoxicillin trihydrate, Amoxil, Amoxil trihydrate, Amoxil Trihydrate, Amoxipen, Amoxipen Trihydrate, Amoxipen trihydrate, Amoxycillin, Amoxycillin Trihydrate, Amoxycillin trihydrate, Amoxicillin, Antibiotic, antimicrobial, polypeptides

Compound Identifiers

PubChem CID

62883