AMG 925

SKU: orb1300495

Description

AMG 925 is an orally active small molecule that potently inhibits both FLT3 and CDK4 kinases, exhibiting IC50 values of 1 nM and 3 nM, respectively. It is utilized in preclinical research for acute myeloid leukemia (AML), demonstrating antitumor efficacy in both cellular assays and animal models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1401033-86-0
• MW: 471.55
• Purity: 99.42%
• Formula: C₂₆H₂₉N₇O₂
• SMILES: C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12
• Target: FLT,CDK
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  CDK1:1.9 μM|CDK6:8 nM|CDK4:3 nM|CDK2:375 nM|FLT3:1 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, FLT3, Fms like tyrosine kinase 3, Inhibitor, AMG 925, AMG925, AMG-925, Cyclin dependent kinase, CDK, CDK1, CDK4, CD135, Cluster of differentiation antigen 135

Compound Identifiers

PubChem CID

60202647