AMG-548 hydrochloride

SKU: orb1686672

Description

AMG-548 hydrochloride is a potent and selective p38α inhibitor (Ki=0.5 nM) with oral activity. It effectively suppresses LPS-induced TNFα production in whole blood (IC50=3 nM) and also inhibits casein kinase 1δ/ε, thereby modulating Wnt signaling pathways. This compound is a valuable tool for investigating inflammation and Wnt-related research in both cellular and animal models.

Research Area

Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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MW	498.02
Formula	C₂₉H₂₈ClN₅O
Target	Others,Casein Kinase,p38 MAPK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Others,Casein Kinase,p38 MAPK

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