AM679

SKU: orb1707675

Description

AM679 is a potent and selective FLAP inhibitor, demonstrating sub-nanomolar activity in binding and human leukotriene assays. It exhibits a favorable CYP profile with no time-dependent inhibition and provides strong oral efficacy in rodent models of airway inflammation, making it a valuable tool for researching leukotriene biosynthesis pathways in both in vitro and in vivo settings.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 1206880-66-1
• MW: 692.87
• Purity: 99.45% (May vary between batches)
• Formula: C₄₀H₄₄N₄O₅S
• SMILES: C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(OC[C@H]3N(C(C)=O)C=4C(C3)=CC=CC4)=CC2)C5=CC=C(C=C5)C=6N=CC(OC)=CN6
• Target: LTR,Cytochromes P450,FLAP
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (4.76 mM);DMSO:≥ 80 mg/mL

Bioactivity

• In Vivo:
  AM679 (10 mg/kg, orally administered 4 hours before ionophore challenge) significantly reduced LTB4 and CysLT levels in rodent bronchoalveolar lavage fluid by 98% and 87% respectively, in the rodent BAL model .
• In Vitro:
  AM679 demonstrated superior activity against Parazacco spilurus subsp. spilurus in hWB (IC50=154 nM) with improved CYP inhibition profiles (IC50 3A4=16.7 μM, 2C9=3.7 μM, 2D6>30 μM) .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM679, AM-679, AM 679

Compound Identifiers

PubChem CID

44627267