AM281

SKU: orb1223198

Description

AM281 is a synthetic cannabinoid CB1 receptor antagonist.

Key Properties

• CAS Number: 202463-68-1
• MW: 557.21
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₉Cl₂IN₄O₂
• SMILES: Ic1ccc(c2n(nc(c2C)C(=O)NN2CCOCC2)c2c(Cl)cc(Cl)cc2)cc1
• Target: HCV
• Solubility: In Vitro: DMSO : 7.14 mg/mL (12.81 mM)

Bioactivity

• In Vivo:
  Animal model: Male NMRI mice with the weight of 25-30 g. Dosage: 0.62, 1.25 and 2.5 mg/kg (chronic administration); 2.5, 5 and 10 mg/kg (acute administration). Administration: Administrated i.p. every day concurrently with morphine except the day of experiment (chronic administration); Singly injected 40 min before second trial (acute administration). Result: The simultaneous daily administration of AM281 with morphine significantly shortened the exploration time, as compared with morphine-dependent mice receiving vehicle. Acute administration at a dose of 5 mg/kg, significantly augmented recognition index.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM281 | AM 281 | AM-281

Quick Database Links

Gene Symbol

HCV