AM-2394

• Catalog Number: orb1304336
• Category: Small Molecules
• Description: AM-2394
• CAS Number: 1442684-77-6
• Purity: 99.62%
• MW: 423.46
• SMILES: O(C=1C(=CN=C(NC(NC)=O)C1)C=2C=CC(OCC(C)(C)O)=NC2)C=3C=C(C)C=NC3
• Formula: C₂₂H₂₅N₅O₄
• Biological Activity: AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.