AM-2394

SKU: orb1304336

Description

AM-2394

Research Area

Metabolism Research

Key Properties

• CAS Number: 1442684-77-6
• MW: 423.46
• Purity: 99.58%
• Formula: C₂₂H₂₅N₅O₄
• SMILES: CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1
• Target: Glucokinase
• Solubility: DMSO:50 mg/mL (118.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.72 mM)

Bioactivity

• Target IC50:
  GKA:60 nM(EC50)
• In Vivo:
  AM-2394, a novel glucokinase activator, prominently reduces plasma glucose levels in ob/ob mice during an oral glucose tolerance test (OGTT) at a 3 mg/kg dosage. It enhances glucokinase's (GK) glucose affinity by roughly 10-fold, showing moderate clearance and favorable oral bioavailability across various animal models. Additionally, AM-2394 significantly improves glucose control following an OGTT in an ob/ob mouse model of diabetes. It demonstrates suitable cross-species plasma clearance, distribution volume, and oral bioavailability, supporting its potential for further investigation in animal studies.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM 2394, AM2394, AM-2394, Inhibitor, Hexokinase IV, Hexokinase D, glucokinase, Glucokinase, inhibit

Compound Identifiers

PubChem CID

71603585