Alvespimycin

SKU: orb1705354

Description

Alvespimycin

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 467214-20-6
• MW: 616.75
• Purity: 99.88%
• Formula: C₃₂H₄₈N₄O₈
• SMILES: CO[C@H]1C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• Target: HSP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.35 mM);DMSO:80 mg/mL (129.71 mM)

Bioactivity

• Target IC50:
  GRP94:65 nM (EC50)|HSP90:62 nM (EC50)
• In Vivo:
  Treatment with vehicle (DMSO) or Alvespimycin(17-DMAG)(10 mg/kg) significantly prolonged the survival time of TCL1-SCID model mice.
• In Vitro:
  After treatment with vehicle control or 1 μM Alvespimycin (17-DMAG) for 24 hours, CLL patient cells showed that Alvespimycin downregulated NF-κB signaling through IKKα and IKKβ.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alvespimycin, 17-DMAG, HSP90, KOS 1022, KOS1022, KOS-1022

Compound Identifiers

PubChem CID

5288674