ALK-IN-26

SKU: orb2281172

Description

ALK-IN-26 is a potent small molecule ALK inhibitor exhibiting anticancer properties. It demonstrates antiproliferative effects in glioblastoma models by inducing apoptosis, autophagy, and necrosis, as evidenced in vitro. This compound is a valuable research tool for studying ALK-driven cancers in cellular assays.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2447607-85-2
• MW: 405.51
• Purity: 99.91% (May vary between batches)
• Formula: C₂₄H₂₃NO₃S
• SMILES: O=S(=O)(C1=CC=C(C=C1)C)N2C=C(C=3C=CC=CC32)CC=4C=C(C(O)=C(C4)C)C
• Target: ALK

Bioactivity

• In Vivo:
  In male C57BL/6J mice, ALK-IN-26 (5 mg/kg; i.v.; single dose) could be rapidly absorbed (Tmax = 0.58 hours) with an acceptable half-life (T1/2 = 3.55 hours) and bioavailability (F = 38.4%).
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• In Vitro:
  In GL261 cells, ALK-IN-26 (0.5 μM, 1.0 μM, 2.0 μM; 24 hours, 48 hours, 72 hours) induced apoptosis of glioblastoma in a concentration- and time-dependent manner, and resulted in cells (24.5%) entering the S phase when treated with 1 μM for 72 hours, but barely proceeding to the G2/M phase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALKIN26, ALK

Compound Identifiers

PubChem CID

169450734