Alexidine dihydrochloride

SKU: orb1308677

Description

Alexidine dihydrochloride

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 1715-30-6
• MW: 581.71
• Purity: 99.81%
• Formula: C₂₆H₅₈Cl₂N₁₀
• SMILES: Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
• Target: Apoptosis,Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.6 mM);DMSO:255 mg/mL (438.36 mM)

Bioactivity

• In Vivo:
  The study primarily investigates biofilm formation by C. Albicans, leveraging an established murine biofilm model for evaluating both existing and novel antifungal compounds. Alexidine dihydrochloride is highlighted for its efficacy, inhibiting 67% of fungal biofilm growth and viability in comparison to control groups, as evidenced by fungal colony-forming unit (CFU) counts. Additionally, microscopic examination of 24-hour-old biofilms within mice jugular vein catheters demonstrates a considerably reduced biofilm density when treated with Alexidine dihydrochloride.
• In Vitro:
  Alexidine dihydrochloride effectively eliminates mature biofilms of Candida, Cryptococcus, and Aspergillus spp., which are typically resistant to nearly all antifungal drugs, at low concentrations (1.5 to 6 μg/mL). It exhibits potent activity against most strains of Candida, achieving minimum inhibitory concentrations (MIC) of ≤1.5 μg/mL for all tested isolates in planktonic form, except for Candida parapsilosis and Candida krusei. Notably, it also demonstrates significant effectiveness against fluconazole-resistant Candida isolates, including strains of C. albicans, C. glabrata, C. parapsilosis, and C. auris. Furthermore, Alexidine dihydrochloride prevents the growth and spread of fungi by entirely inhibiting filamentation and biofilm dispersal, specifically at concentrations significantly lower than those harmful to human cells (150 ng/mL versus 5- to 10-fold higher concentrations for 50% killing of HUVECs and lung epithelial cells).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antifungal, antibiofilm, anticancer, Apoptosis, apoptosis, AXD, Alexidine, Alexidine Dihydrochloride, Alexidine dihydrochloride, inhibit, mitochondrial, Inhibitor, Fungal, phosphatase, PTPMT1, tyrosine

Compound Identifiers

PubChem CID

102678