Aleplasinin

SKU: orb1304769

Description

Aleplasinin (PAZ 417) is an orally bioavailable, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1), a primary regulator of fibrinolysis. Its application in research includes in vitro enzymatic assays and in vivo models for studying Alzheimer's disease pathology and other conditions involving impaired fibrinolytic activity.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 481629-87-2
• MW: 425.52
• Purity: 97.51% (May vary between batches)
• Formula: C₂₈H₂₇NO₃
• SMILES: Cc1cccc(c1)-c1ccc2n(Cc3ccc(cc3)C(C)(C)C)cc(C(=O)C(O)=O)c2c1
• Target: PAI-1,Beta Amyloid
• Solubility: DMSO:245 mg/mL (575.77 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.75 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BBB-penetrated, Amyloid-β, Aleplasinin, Alzheimer's disease, Abeta, PAZ 417, PAZ417, PAZ-417, PAI1, PAI-1, inhibit, memory deficiency, Inhibitor, Plasminogen activator inhibitor-1, orally active, Serpin family, β-amyloid peptide

Compound Identifiers

PubChem CID

10224267