Akt3 degrader 1

SKU: orb1982441

Description

Akt3 degrader 1 is a selective small molecule degrader of Akt3, demonstrating antiproliferative and antitumor activity in preclinical models. It is utilized in cancer research, particularly for studying non-small cell lung cancer and pancreatic cancer, with evidence of efficacy in both in vitro assays and in vivo mouse studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2836342-69-7
• MW: 885.19
• Purity: 98.12% (May vary between batches)
• Formula: C₅₃H₇₂N₈O₄
• SMILES: O=C1C=C(C=2C=NC(=NC2N1C=3C=CC=C(C3)NC(=O)C4CC4)NC5=CC=C(C=C5OC)N6CCN(CC6)CCCCCCCCCCCCNC(=O)CC78CC9CC(CC(C9)C7)C8)C
• Target: Akt

Bioactivity

• In Vivo:
  In NOD-SCID-IL2Rg-/- ( NSI ) mice ( H1975OR xenograft model ), Akt3 degrader 1 ( 10,20 mg/kg ; intraperitoneal administration ; every 3 days for 5 weeks ) can Inhibited tumor growth without causing obvious body weight loss or other signs of toxicity.
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• In Vitro:
  In H1975OR cells, Akt3 degrader 1 ( 0.001-100 μM ; 24 h ) could inhibit the growth of H1975OR cells with an IC50 of 0.972 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt3

Compound Identifiers

PubChem CID

165437257