(-)-Agelastatin A

SKU: orb1701451

Description

(-)-Agelastatin A is a marine-derived pyrrole-aminoimidazole alkaloid with potent antiproliferative activity against cancer cell lines, including leukemia and breast cancer, in vitro. It functions by inhibiting molecular targets such as β-catenin and GSK-3β, and its CNS-penetrant properties support research in neuro-oncology and in vivo model studies.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 152406-28-5
• MW: 341.16
• Formula: C₁₂H₁₃BrN₄O₃
• SMILES: BrC=1N2[C@]3([C@]([C@]4([C@@](O)(C3)N(C)C(=O)N4)[H])(NC(=O)C2=CC1)[H])[H]
• Target: Others

Bioactivity

• Target IC50:
  Daudi cells:20 nM|CA46 cells:187 nM|HeLa cells:708 nM|A549 cells:1.05 μM|IMR90 cells:1.11 μM|Jurkat cells:74 nM|BT-549 cells:278 nM|U-937 cells:67 nM|CEM cells:20 nM|HL-60 cells:138 nM
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• In Vitro:
  Methods: Agelastatin A (0-2 μM, 48 h) was used to treat U-937, HeLa, A549, BT549 and IMR90 cells, and the IC50 values at 48 hours were determined by MTS. Results: The IC50 values of U-937, HeLa, A549, BT549 and IMR90 cells were 67 nM, 708 nM, 1.05 μM, 278 nM and 1.11 μM, respectively. Methods: CEM, Jurkat, Daudi, HL-60 and CA46 cells were treated with Agelastatin A (0-1 μM, 48 h). The IC50 values at 48 h were determined by MTS assay. Results: The IC50 values of CEM, Jurkat, Daudi, HL-60 and CA46 cells were 20, 74, 20, 138 and 187 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Agelastatin A, AglA, ( ) Agelastatin A, ()Agelastatin A

Compound Identifiers

PubChem CID

177936