AG-636

SKU: orb1298351

Description

AG-636

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 1623416-31-8
• MW: 343.38
• Purity: 99.19% (May vary between batches)
• Formula: C₂₁H₁₇N₃O₂
• SMILES: Cc1ccccc1-c1ccc(cc1)-c1cc(C(O)=O)c2n(C)nnc2c1
• Target: Dehydrogenase|||DNA/RNA Synthesis
• Solubility: DMSO:31.25 mg/mL (91.01 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.82 mM)

Bioactivity

• Target IC50:
  DHODH:17 nM
• In Vivo:
  AG-636 (10-100 mg/kg; oral gavage; twice daily; for 14 days) treatment significantly inhibits tumor growth in the OCILY19 DLBCL tumor xenograft model.
• In Vitro:
  AG-636, in cancer cell lines of hematologic versus solid tumor origin. Differential AG-636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, oral, inhibit, AG 636, AG636, AG-636, anticancer, DHODH, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Dihydroorotate Dehydrogenase, RNASynthesis, RNA Synthesis, reversible

Compound Identifiers

PubChem CID

77461001