AG-270

SKU: orb1298411

Description

AG-270 is a potent, orally bioavailable allosteric inhibitor of MAT2A. It is used in cancer research, particularly for studying MTAP-deleted tumors, and has demonstrated activity in both cellular assays and in vivo models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2201056-66-6
• MW: 489.57
• Purity: 98.28%
• Formula: C₃₀H₂₇N₅O₂
• SMILES: COc1ccc(cc1)-c1c(Nc2ccccn2)[nH]c2c(c(nn2c1=O)-c1ccccc1)C1=CCCCC1
• Target: Methionine Adenosyltransferase (MAT)
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Mat2A:14 nM
• In Vitro:
  AG-270 exhibits an IC50 of 20 nM in HCT116 MTAP-null cell SAM at 72 h.AG-270 demonstrates potent reduction in levels of intracellular SAM, as well as MTAP-null–selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

toxicity, tumor, solid, SAM, cancer, AG270, AG-270, AG 270, MAT, MAT2A, pancreatic, lymphoma, MethionineAdenosyltransferase(MAT), MethionineAdenosyltransferase, Methionine Adenosyltransferase (MAT), Methionine Adenosyltransferase, Inhibitor, Low, inhibit

Compound Identifiers

PubChem CID

134307820