AG 126

SKU: orb1223404

Description

AG 126 selectively inhibits the phosphorylation. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

Key Properties

• CAS Number: 118409-62-4
• MW: 215.17
• Purity: >98% (HPLC)
• Formula: C₁₀H₅N₃O₃
• SMILES: C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]
• Target: Akt
• Solubility: DMSO : 100 mg/mL. 464.75 mM

Bioactivity

• In Vivo:
  AG 126 (intraperitoneal injection; 1-10 mg/kg; 1 h and 6 h after Zymosan treatment) treatment attenuates the degree of multiple organ failure (MOF) associated with Zymosan-induced peritonitis in the rat. Animal model: Male Sprague-Dawley rats treated with Zymosan (500 mg/kg). Dosage: 10 mg/kg, 3 mg/kg or 1 mg/kg. Administration: Intraperitoneal injection; 10, 3, or 1 mg/kg; 1 h and 6 h after Zymosan treatment. Result: Attenuated the peritoneal exudation and the migration of polymorphonuclear cells caused by Zymosan in a dose-dependent fashion. Attenuated the lung, liver, and intestinal injury. Reduced the production of peroxynitrite and of pro-inflammatory cytokines TNF-alpha and IL-1beta.
• In Vitro:
  AG126 (10 μM; overnight) increases the viability of ARPE-19 cells. AG126 at concentrations higher than 10 μM show toxic to ARPE-19 cells and can enhance H2O2 toxicity. AG126 (0.1-100 μM) inhibits VEGF-induced proliferation of BRMECs. Cell Viability Assay Cell line: ARPE-19 cells. Concentration: 10 μM. Incubation time: Overnight. Result: Increased the viability of ARPE-19 cells to 35-72% compared to the control. Cell Proliferation Assay Cell line: BRMECs. Concentration: 0.1-100 μM Incubation time: Result: Inhibited VEGF-induced proliferation of BRMECs in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG 126 | Tyrphostin AG 126 | UNII-7YA4AMD1JC

Quick Database Links

Gene Symbol

Akt