Adrenalone hydrochloride

SKU: orb1310141

Description

Adrenalone hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62-13-5
• MW: 217.65
• Purity: 99.91%
• Formula: C₉H₁₁NO₃·HCl
• SMILES: Cl.CNCC(=O)c1ccc(O)c(O)c1
• Target: Adrenergic Receptor
• Solubility: DMSO:60 mg/mL (275.67 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.19 mM);H2O:40 mg/mL (183.78 mM)

Bioactivity

• In Vivo:
  Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively.
• In Vitro:
  Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenergic Receptor, Adrenalone HCl, Adrenalone hydrochloride, Adrenalone Hydrochloride, Adrenalone, AdrenergicReceptor, Beta Receptor, inhibit, kinase, Inflammasome, Inflammation, PAR, Pyroptosis, Inhibitor, GPVI, Syk, Src, Potassium, signaling, Piceatannol, α1-adrenergic receptor, Tyrosine

Compound Identifiers

PubChem CID

66136