Adenosine Dialdehyde (ADOX)

SKU: orb1306058

Description

Adenosine dialdehyde, a periodate-oxidized adenosine analog, is a potent and selective inhibitor of S-adenosylhomocysteine hydrolase (SAHH) with a Ki of 3.3 nM. This compound is a valuable research tool for studying methylation-dependent processes and has demonstrated anti-tumor activity in vivo models.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 34240-05-6
• MW: 265.23
• Purity: 95.00% (May vary between batches)
• Formula: C₁₀H₁₁N₅O₄
• SMILES: C(OC(CO)C=O)(C=O)N1C=2C(N=C1)=C(N)N=CN2
• Target: Others
• Solubility: DMSO:102 mg/mL (384.57 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

• In Vivo:
  Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.
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• In Vitro:
  Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adenosine Dialdehyde, Adenosinedialdehyde, Adenosine, periodate oxidized, Adenox, ADOX, S-adenosylhomocysteine hydrolase, Periodate-oxidized adenosine

Compound Identifiers

PubChem CID

99920