ACY-957

SKU: orb1710490

Description

ACY-957 (C001) is a potent, orally bioavailable small molecule that selectively inhibits HDAC1 and HDAC2 with IC50 values of 7 nM and 18 nM, respectively, while showing minimal activity against HDAC3 and other class I/II HDACs. This selectivity profile makes it a valuable chemical probe for epigenetic research in oncology and neurology, supporting both in vitro mechanistic studies and in vivo disease model investigations.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1609389-52-7
• MW: 429.54
• Purity: 98.24% (May vary between batches)
• Formula: C₂₄H₂₃N₅OS
• SMILES: Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
• Target: HDAC
• Solubility: DMSO:50 mg/mL (116.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM)

Bioactivity

• Target IC50:
  HDAC2:18 nM|HDAC1:7 nM|HDAC3:1300 nM
• In Vitro:
  ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50 values of 7 nM for HDAC1, 18 nM for HDAC2, and 1300 nM for HDAC3, showing no inhibition of HDAC4/5/6/7/8/9. It exhibits an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC3, HDAC1, HDAC Inhibitor C 001, HDAC Inhibitor C001, HDAC Inhibitor C-001, HDAC2, ACY 957, ACY957, ACY-957

Compound Identifiers

PubChem CID

72374405