aCx26-pep

• Catalog Number: orb1821036
• Category: Proteins
• Description: Cx26 interaction region mimetic; Cell penetrating peptides.
• Modifications: C terminal amide.
• Structure: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Arg-Tyr-Cys-Ser-Gly-Lys-Ser-Lys-Lys-Pro-Val-NH2
• Target Areas: Nuclear receptor modulators, Protein-protein interactions
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 3477.97 Da
• Formula: C₁₅₈H₂₆₀N₅₂O₃₃S₂
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Arg-Tyr-Cys-Ser-Gly-Lys-Ser-Lys-Lys-Pro-Val-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: Cx26 peptide
• Background: aCx26-pep is a peptide consisting of the gap junction protein connexin 26 (Cx26) cytosolic tail sequence, coupled to antennapedia. Triple negative breast cancer (TNBC) is one of the most lethal and treatment resistant breast cancer subtypes and it contains a unique protein complex composed of Cx26, the pluripotency transcription factor NANOG, and focal adhesion kinase (FAK), with the Cx26 cytosolic tail being essential for interaction with NANOG and FAK. In vitro, in breast cancer cells, aCx26-pep treatment decreases FAK and NANOG levels and alters NANOG function, and also decreases tumoursphere frequency. In vivo, in an NSG mouse model, aCx26-pep reduces TNBC tumour growth and proliferation and induces cell death.
• Note: For research use only
• Expiration Date: 6 months from date of receipt.