ACTH 11-24 acetate(4237-93-8 free base)

SKU: orb1296695

Description

ACTH (11-24) acetate is a synthetic peptide fragment of adrenocorticotropic hormone. It acts as a competitive antagonist of full-length ACTH, inhibiting cortisol release in vitro, and is used in research to study adrenal cortex signaling and hormone regulation mechanisms.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 79190-56-0
• MW: 1712.12
• Purity: 100.00%
• Formula: C₇₉H₁₃₈N₂₄O₁₈
• SMILES: CC([C@H](NC([C@@H]1CCCN1C([C@@H](N)CCCCN)=O)=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3CCC[C@H]3C(O)=O)=O)CC4=CC=C(O)C=C4)=O)C(C)C)=O)CCCCN)=O)C(C)C)=O)=O)CCC/N=C(N)\N)=O)CCC/N=C(N)\N)=O)CCCCN)=O)CCCCN)=O)=O)C.CC(O)=O
• Target: Melanocortin Receptor,Endogenous Metabolite
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  ACTH (11-24) blocks electroacupuncture (EA) anti-edema but not EA anti-hyperalgesia in rats.
• In Vitro:
  ACTH (11-24) acts as an antagonist of adrenocorticotropic hormone receptor. ACTH (11-24) induces cortisol secretion submaximally in freshly dispersed or cultured beef adrenal cortical cells. The maximal cortisol release by ACTH (11-24) is enhanced by forskolin but inhibited by calcium channel blockers.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adrenocorticotropic Hormone, Adrenocorticotropic Hormone Acetate, Adrenocorticotropic Hormone (11-24) acetate, ACTH 11 24 acetate(4237 93 8 free base), ACTH 1124 acetate(4237938 free base), ACTH 11-24 acetate(4237-93-8 free base), Melanocortin Receptor, Melanocortin Receptors, MelanocortinReceptor

Compound Identifiers

PubChem CID

155977577