ACT001

SKU: orb1689826

Description

ACT001 is an orally active PAI-1 inhibitor by inhibiting the phosphorylation of PI3K and AKT. ACT001 inhibits the phosphorylation of STAT3 and PD-L1 expression by directly binding to STAT3. ACT001, a fumarate salt form of DMAMCL (a prodrug of Micheliolide), can cross the blood-brain barrier. ACT001 has a synergistic effect with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. ACT001 has potent anti-glioblastoma (GBM) activity and immunomodulatory effects.

Key Properties

• CAS Number: 1582289-91-5
• MW: 409.479
• Formula: C₂₁H₃₁NO₇
• SMILES: OC(=O)\C=C\C(O)=O.[H][C@@]12CCC(C)=C3CC[C@@](C)(O)[C@]3([H])[C@@]1([H])OC(=O)[C@H]2CN(C)C
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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